Experience from the use of absorbable type I collagen as haemostatic agent in obstetric and gynecological operations

Hippokratia 2006, 10(4):182-184

V Karagiannis, A Daniilidis, D Rousso, V Palapelas, T Karagiannis, D Kiskinis
3rd Dpt Obstetrics and Gynaecology, Hippokratio Hospital, Thessaloniki, Greece
1st Cardiology Clinic, Papageorgiou Hospital, Thessaloniki, Greece


During the third stage of labour there are a lot of causes of significant hemorrhage. The commonest causes of acute hemorrhage are the uterine atony, the retained placenta, the lower tract lacerations, uterine rupture, placenta accreta, hereditary coagulopathy. Also, there could be significant bleeding, during caesarian section, usually at the time of removal of the placenta in cases of low lying placenta or placenta previa. A lot of times we have to confront serious hemorrhages in gynecological procedures like hysterectomies in cases of cervical, uterine or ovarian cancers. In order to deal with these problems successfully, general and specific measures are being taken. In cases of atonic uterus when all the other methods are unsuccessful we have to proceed to ligation of the internal iliac artery or even hysterectomy.
Material-Methods: We have tried to use the hemostatic type I collagen in obstetrical and gynecological cases in order to control the bleeding. We have used the collagen type I totally in 8 cases. Five of them were cases of atonic uterus after normal delivery or caesarian section and three of them were gynecological cases of uterine fibroids and ovarian cancer.
Results and conclusions: By placing the collagen type I over the bleeding surfaces we have realized that in a very short period of time, there has been satisfactory control of the bleeding and immediate clinical improvement of the patient. In four out of five obstetrical cases that we have used the type I collagen, we have managed to avoid the hysterectomy.

Keywords: type I collagen, post partum hemorrhage, caesarian section, gynecological operations

Correspoding author: Karagiannis V, e-mail: karagian@med.auth.gr