Treatment of Paget’s disease with administration of zoledronic acid

Hippokratia 2004, 8(1):7-10

N Krikis, K Tziomalos, G Sfikas, A Karagiannis, V Perifanis, V Georgopoulou, A Papanikolaou, F Harsoulis
2nd Propedeutic Dpt of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Grrece
1st Radiology Dpt, Hippokratio General Hospital, Thessalonki, Greece


A case of an asymptomatic patient with Paget’s disease who was treated with zoledronic acid is reported. The diagnosis was based on radiological findings, histology and elevated alkaline phosphatase. The elevated alkaline phosphatase was decreased and remained within normal range for fifteen months, following a single intravenous administration of 4mg zoledronic acid, whereas the radiologic findings remained unchanged. The role of biphosphonates in Paget’s disease is reviewed and the comparative advantages of zoledronic acid are pointed out.