Mycophenolate Mofetil in Transplantation

Hippokratia 2002, 6(4):163-166

G Vergoulas


Mycophenolate mofetil (MMF) blocks the de novo pathway of purine production in the lymphocytes and more specifically the production of guanocine by inhibiting the action of inosine monophosphate dehydrogenase. The result of this action is the inhibition of Τ and Β lymphocyte proliferation and the inhibition of antibody production by Β lymphocytes.