The role of antithrombine III in sepsis

Hippokratia 1999, 3(4):160-165

Ch. Tsiotras


Sepsis represents a systematic inflammatory reaction of the organism to infection. The septic procedure results in activation of the coagulation mechanism and the intravascular consumption of the clotting factors and AT III, depending on the severity of Sepsis. AT III is a coagulation mechanism balance regulator and has anti-inflammatory properties. As the microcirculation thromboembolic impairment and the intravascular consumption of the coagulation factors develop early during the septic process – before the multiple organ dysfunction appears-we could suggest the early replacement of the AT III deficit, by administering concentrated AT III preparation in order to eliminate the infectious reaction. The phase III results of the relative clinical randomized polycentric trials are being expected.