Natural anticoagulants and lipid profile in hemodialysis patients

Hippokratia 1998, 2(1):28-31

R. Tsitamidou, K. Kynigopoulou, Gr. Dimitriadis, M. Tsardaki, K. Sombolos


Patients undergoing hemodialysis (HD) are subject to risk of thrombotic events. Lipid disorders and abnormalities in hemostatic variables have been implicated in thrombotic events. Study’s aim was to measure the plasma levels of natural anticoagulants and lipid profile in uremic patients treated with HD.In 41 non-diabetic uremic patients and in 20 healthy volunteers protein C(PC), protein S(PS) antithrombin III (ATIIII), TC, Tr, LDL-C, HDLC, Apo-A, Apo-B were measured. Results showed that HD patients had higher levels TC, Tr, LDL-C and lower values of protein C than controls. In conclusion, the lower plasma activity of PC and uremic dyslipidemia may lead to increased risk of thrombosis.